RRM2, a rate-limiting enzyme functioning in the formation of ribonucleotides into deoxyribonucleotides, is very important for DNA replication (Koppenhafer et al., 2020), which is overexpressed in various tumor progression, leading to poor prognoses (Li et al., 2018; Mazzu et al., 2019; Jin et al., 2020). Here, RRM2 is linked to neoplasm.