Specifically, it has been reported that CTHRC1 regulates tumor progression through the CTHRC1/Wnt/β-catenin pathways in breast cancer (Lai et al., 2017), non-small cell lung cancer (Ke et al., 2014), and oral cancer (Liu et al., 2013). The gene discussed is CTHRC1; the disease is lip and oral cavity carcinoma.