GRN and cancer: Tang et al. had indicated that GRN bound directly to tumor necrosis factor receptors (TNFRs) and disturbed the TNFα-TNFR interaction (Tang et al., 2011), while TNFα is responsible for a diverse range of signaling events within cells, leading to necrosis or apoptosis, and also important for resistance to cancers (So and Ishii, 2019).