We found CAFs which highly expressed CTHRC1 (from F04 and F08) and tumor associated macrophages were mediated by a different set of ligand-receptor pairs, including THY1/aXb2 complex, GRN/TNFRSF1A, CD99/PILRA, CD74/MIF, APP/CD74, ANXA1/FPR1, etc. The gene discussed is MIF; the disease is neoplasm.