ANGPTL4 and gastric cancer: We found many angiogenesis associated genes showed consistent expression trend of CTHRC1 in gastric cancer, such as ACVRL1, ANGPTL3, ANGPTL4, NOTCH4, VEGFB, VEGFC etc. (Figure 5A) Immunofluorescence staining showed that CTHRC1 was present in the vascular tissue surrounding the gastric tumors (Figure 5B), suggesting that CTHRC1 may participate in extracellular matrix remodeling in gastric tumor angiogenesis.