By analyzing the correlation of FCNs expression with tumor mutation burden and microsatellite instability in 33 type of human tumors, FCN1 expression was found to be significantly correlated with MSI of HCC (p < 0.05); FCN3 expression was significantly correlated with TMB and MSI of HCC (p < 0.05) (Figure 10). Here, FCN3 is linked to hepatocellular carcinoma.