Our findings revealed that Montelukast could attenuate lung dysfunction during CLP-induced polymicrobial sepsis in male mice through their modulating effects on pro-inflammatory and oxidative stress downstream signalling pathways and subsequently decreased lung tissue levels of cytokines (IL-1β, IL-6, IL-17, LTB-4 and 12(S) HETE). The gene discussed is IL17A; the disease is Sepsis.