Serum from COVID-19 patients and individuals assessed months before the COVID-19 pandemic was also applied to a protein/peptide microarray to detect IgM and IgG binding to SARS-CoV-2 structural proteins and overlapping LPEs, including variants associated with distinct SARS-CoV-2 isolates, and proteins from other human respiratory viruses (Figure S2b and Table S1). This evidence concerns the gene CD40LG and COVID-19.