DYRK1A is also known to phosphorylate Tau at multiple sites including serine 262 that results in aggregation of pathological Tau neurofibrillary tangles associated with sporadic AD (Woods et al., 2001; Liu et al., 2008; Shi et al., 2008; Azorsa et al., 2010; Frost et al., 2011; Wegiel et al., 2011; Tenreiro et al., 2014). This evidence concerns the gene DYRK1A and Alzheimer disease.