Furthermore, PST-001 is void of activity against the protein kinase GSK3β, that is involved in Tau phosphorylation and NFT formation (Toral-Rios et al., 2020) as well as contributing to the effects of AD through the Wnt pathway (Hooper et al., 2008), enabling the separation of DYRK1A mediated effects over GSK3β effects in in vivo models. Here, DYRK1A is linked to Alzheimer disease.