DYRK1A and Alzheimer disease: We next wished to test if the reduction of neurotoxicity conferred by the DYRK1A inhibitor could have further beneficial effects on our fly models of AD-DS, which is associated with a significant reduction in lifespan (Querfurth and LaFerl a, 2010; Selkoe and Hardy, 2016; Mukhopadhyay and Banerjee, 2021).