Previous work suggests that PST-001 shows inhibition across the DYRK-family (human DYRK1A, DYRK2 and DYRK3) as well as being effective associative memory deficits in Ts65 Dn DS model mice (Stensen et al., 2021b), this and our data therefore is consistent PST-001 being highly effective against Drosophila DYRK1A (the product of the mnb gene). The gene discussed is DYRK2; the disease is Dravet syndrome.