We compared the effect of neuronal overexpression of the fly ortholog of DYRK1A called mnb, human Tau or human Aβ42 and found they caused a range of AD and AD-DS relevant phenotypes in Drosophila including degeneration of the photoreceptor neurons, shortened lifespan, motor impairment, sleep, and memory loss. Here, MAPT is linked to Dravet syndrome.