In order to compare the effects of the different behavioural effects of the neurotoxic genes and test if the DYRK1A antagonist treatment could improve behavioural deficits associated with AD-DS (Querfurth and LaFerl a, 2010; Wiseman et al., 2015; Ballard et al., 2016), we measured a locomotor response assessed using the negative geotaxis assay in young (2–5 days post hatching) flies which was shown to be decreased by overexpression of these genes (Higham et al., 2019a; Lowe et al., 2019). This evidence concerns the gene DYRK1A and Alzheimer disease.