Likewise, neuronal overexpression of AD-associated human Tau isoforms also result in degeneration of the photoreceptor neurons, central brain neurodegeneration, shortened lifespan, movement, changes in neuronal excitability, circadian rhythm, sleep, and learning defects (Wittmann et al., 2001; Folwell et al., 2010; Iijima-Ando and Iijima, 2010; Kosmidis et al., 2010; Beharry et al., 2013; Papanikolopoulou and Skoulakis, 2015; Sealey et al., 2017; Higham et al., 2019a; Higham et al., 2019b; Buhl et al., 2019; Lowe et al., 2019). The gene discussed is MAPT; the disease is Alzheimer disease.