Reduced CASP8 expression has also been linked to certain neoplastic behaviors such as metastasis (Kordi Tamandani et al., 2009; Zhu et al., 2010), for instance in a breast cancer cell line (MDA-MB-231), decreased CASP8 expression was associated with increased tumor migration and invasion [36], and therefore, it remains possible that an up-regulation of CASP8 may confer a survival advantage. The gene discussed is CASP8; the disease is breast cancer.