Jablonsik et al. have demonstrated that single nucleotide polymorphisms of Cacna2d1, the subunit of alpha2/delta-1 in voltage-dependent calcium channel, are associated with intracellular Ca2+ concentration, cell contractility, cytoskeleton, and stiffness of the TM, which eventually lead to the pathogenesis of primary open-angle glaucoma (Chintalapudi et al., 2017). This evidence concerns the gene CACNA2D1 and open-angle glaucoma.