ALPK1 and inflammatory bowel disease: Analyses of the pathway scores in an OPLS-DA revealed a strong separation between the groups (p<0.0001; Figure 2A), with most pathways scores increased in active IBD except for alpha kinase-1 (ALPK1), autophagy, IL-17 signaling and leukotriene and prostaglandin inflammation pathways, which were decreased in active IBD compared with healthy subjects (Figure 2B).