In addition, genes linked to autophagy (BEC1, ATG10, ULK2, RB1CC1, MAP1LC3A, PIK3R4, PIK3C3), IL-17 receptor signaling cascades (RPS6KA1, IL17RB, IL17RC, ATF2, RPS6KA3, MAP2K4, Table 1, IL17RE), ALPK1 signaling (TAB2, Table 1, TRAF6, MAP3K7) and prostaglandin degradation (HPGD, EPHX2), were downregulated in active IBD compared with healthy subjects (Figure 2C). The gene discussed is PIK3R4; the disease is inflammatory bowel disease.