MAP2K4 and inflammatory bowel disease: In addition, genes linked to autophagy (BEC1, ATG10, ULK2, RB1CC1, MAP1LC3A, PIK3R4, PIK3C3), IL-17 receptor signaling cascades (RPS6KA1, IL17RB, IL17RC, ATF2, RPS6KA3, MAP2K4, Table 1, IL17RE), ALPK1 signaling (TAB2, Table 1, TRAF6, MAP3K7) and prostaglandin degradation (HPGD, EPHX2), were downregulated in active IBD compared with healthy subjects (Figure 2C).