REN and inflammatory bowel disease: In a cascade of events, angiotensinogen is cleaved to angiotensin (AT) II, activating numerous cell types including intestinal epithelial cells, immune cells and stromal fibroblasts.41 Although RAS has a major role in inflammation, fibrosis, immune cell recruitment and apoptosis, little is known about RAS in IBD.42 Still, overexpression of renin increases susceptibility to experimental colitis.43 In our study, the angiotensin system pathway score was downregulated in UC remission but not affected in active UC or CD.