This was identified through hyperphosphatemia inducing senescence in cultured myoblasts through ILK overexpression via gene transfer using adenoviral expression vectors encoding ILK gene, lowers cell replication capacity since older mice have a considerable loss of muscle strength, which correlates with hyperphosphatemia and increased ILK and p53 (Sosa et al., 2018). Here, ILK is linked to hyperphosphatemia.