The proinflammatory role of IL-17 is recognized in metabolic- and aging-associated diseases (Bechara et al., 2021), (Chen et al., 2020), (Mohammadi Shahrokhi et al., 2018), and our previous work showed that obesity and palmitate partially recapitulated a T2D-associated cytokine profile (McCambridge et al., 2019). The gene discussed is IL17A; the disease is obesity due to melanocortin 4 receptor deficiency.