We focused on the biomarkers associated with the severity of PV and found that in the MP subgroup, SM (d16:0/17:1) and SM (d19:1/20:0) were positively correlated with the PASI, whereas in the SP subgroup, PC (18:0/22:4), PC (20:0/22:4), and Cer (d18:1/18:0) were positively correlated with PASI scores. The gene discussed is CBLN1; the disease is acquired polycythemia vera.