Some studies have examined the function of 14-3-3 proteins in viral infection; for instance, 14-3-3ε has been reported to competitively bind RIG-I with the NS3 protein of Zika virus, resulting in blocked binding of RIG-I with downstream MAVS and weakening the antiviral effect mediated by RIG-I (Riedl et al., 2019). This evidence concerns the gene RIGI and viral infectious disease.