Jang et al. (2019) characterized the global profile of TE onco-exaptation across different cancer types and highlighted the TE cryptic promoter-activation events as an important mechanism for oncogene activation and tumorigenesis, including the HERVH-SLCO1B3 transcript, which was onco-exaptation in various cancer types. Pontis et al. (2019) showed that Krüppel-associated box (KRAB)-containing zinc finger proteins (KZFPs) controlled the activation of transcriptional cis regulators derived from HERV-K and HERV-H subgroups during early embryogenesis. This evidence concerns the gene ZNF146 and cancer.