SERPINE2 gene expression was also dramatically increased in CRC cells compared with normal IECs; In the HCT116 cell, SERPINE2 knockdown distinctly decreased the anchorage-independent growth, tumor formation, and cell migration in nude mice; SERPINE2 mRNA level in CRC cell lines was markedly decreased by U0126 (a highly specific MEK1/2inhibitor) administration (21). The gene discussed is SERPINE2; the disease is colorectal carcinoma.