The panel of CEA + IL-6+IL-8 has the best diagnostic efficacy for lung cancer than CEA alone or CEA combined with IL-1β, IL-6 and IL-8 respectively; In addition, we also demonstrated for the first time that the panel containing IL-8 and CEA could be the promising molecular biomarker panel to predict the metastasis of lung cancer. This evidence concerns the gene IL6 and lung cancer.