Few CSPalpha-positive and synaptophysin-positive structures co-localized with Aβ in Alzheimer’s disease and control brains (Braak VI, 3.7 ±1.9% and controls, 0.3 ±0.3%) (Plaque status effect; t = 2.053, P = 0.0472) (Figs 7F and J and 8D). The gene discussed is SYP; the disease is early-onset autosomal dominant Alzheimer disease.