These mice harbour FAD-causing mutations in human APP and PSEN1 genes, progressively develop Aβ plaques from as early as 3 months of age and show age-dependent neuroinflammation, synaptic abnormalities, neuronal loss and cognitive decline.35 Six-month-old 5xFAD mice exhibited prominent Aβ labelling marking intraneuronal APP and Aβ that was absent in the hippocampus of WT mice (Fig. 4A and B). This evidence concerns the gene APP and Mental deterioration.