Of the CSPalpha structures analysed, 12.2 ±4.0% co-localized with synaptophysin in Alzheimer’s disease compared with control BA9 (2.6 ±1.7%) (Plaque status effect; t = 5.362, P < 0.001) (Fig. 8C). This evidence concerns the gene SYP and early-onset autosomal dominant Alzheimer disease.