SYP and early-onset autosomal dominant Alzheimer disease: Plaque-associated synaptophysin accumulations, possibly linked to pre-synaptic dystrophies or degenerating synapses, were found to be more dense with increasing Aβ plaque load in Alzheimer’s disease and control brains (Braak VI, 8.3 × 107 ±8.6 × 106 objects/mm3 and controls, 6.9 × 107 ±1.8 × 107 objects/mm3) (t = 2.84, P < 0.01) (Fig. 8B).