SNAP25 and early-onset autosomal dominant Alzheimer disease: SNAP-25 is an interacting partner of CSPalpha at pre-synapses that has previously been shown to accumulate in Alzheimer’s disease brain.54,57 SNAP-25 labelled the pre-synaptic neuropil as previously reported,58 and some, but not all, SNAP-25 immunoreactive structures also labelled with CSPalpha, particularly for the larger amorphous deposits (Fig. 6B).