The midbrain DR of SUDEP revealed activated pathways related to G-protein signalling (Gbeta gamma, GNRH, opioid signalling), inflammatory response (CCR3, MAPK signalling inpromoting pathogenesis of influenza), stress response (xenobiotic metabolism generalsignalling pathway, endothelin-1 signalling), and neuronal migration/outgrowth (CDK5signalling). This evidence concerns the gene EDN1 and influenza.