Although CSPG4 has the unique capability to affect numerous cell behaviors and cellular processes and has a wide range of ECM ligands that facilitate CSPG4 to serve as a pharmacologic mediator in controlling the neurovascular signaling network, whether CSPG4 could serve as a therapeutic target of neuroprotection in ischemic stroke has not been explored. The gene discussed is CSPG4; the disease is ischemic stroke.