SMO and infectious otitis media: Consistent with the previous studies, the present study showed that WMP inhibited the Shh level, decreased the expression of Patched and Smo, and increased the expression of Hhip together with suppression of the nuclear translocation of Gli 1 in AOM/DSS-induced CAC mice, showing potent inhibition effect on Hh signaling in AOM/DSS-induced CAC in vivo.