PARK7 and non-small cell lung carcinoma: Cao et al. reported that inhibition of DJ-1 potently enhanced the sensitivity of tumor cells to ferroptosis inducers in HT1299 human non-small-cell lung cancer (NSCLC), and the mechanism study found that DJ-1 depletion could inhibit the transsulfuration pathway by disrupting the formation of AHCY tetramer and impairing AHCY activity, suggesting that AHCY linked to the sensitivity of tumor cells to the ferroptosis inducer in NSCLC [60].