Moreover, depletion of AHCY enhanced the enzyme activities of GSH-Px and SOD in SW620 (Figures 6(m) and 6(n)), while overexpression of AHCY weakened the enzyme activities of GSH-Px and SOD in DLD-1 cells (Figures 6(o) and 6(p)), suggesting that AHCY could promote oxidative stress in colon cancer cells. Here, SOD1 is linked to malignant colon neoplasm.