KPNA3 and KPNA4 were also studied regarding the transport of TAR DNA-binding protein 43 (TDP-43) and the formation of aggregates of this protein in the central nervous system (Pasha et al., 2021), which is a hallmark of many neurodegenerative diseases (Jo et al., 2020). The gene discussed is KPNA3; the disease is neurodegenerative disease.