IL6 and plasma cell myeloma: The continuously activated NF-κB in Tregs or other cells can enhance the transcription of VEGF genes and also increase the levels of some tumor promoting cytokines, such as IL-1 (acute leukemia growth factor), TNF (malignant lymphogranuloma, T cell lymphoma, glioma growth factor), and IL-6 (growth factor for multiple myeloma), thereby promoting the above signaling pathways regulated by VEGF and IL-6.