Worth noting is that while SNPs in CLCN6 are associated with lower DP, they have also been found to be associated with seizure and epilepsy in some populations (Wang et al., 2017; Yamamoto et al., 2015), and a Clcn6 deficient mouse had characteristics of mild neuronal ceroid lipofuscinosis, a lysosomal storage disease (Poet et al., 2006). Here, CLCN6 is linked to epilepsy.