MTHFR and stroke disorder: Additionally, the AGTRAP‐PLOD1 locus gene cluster where CLCN6 is localized has been associated with stroke along with other BP regulatory genes such as MTHFR, NPPA, and NPPB, (Del Greco et al., 2011; Flister et al., 2013; Pereira et al., 2015; Yang et al., 2014).