A US population-based case–control study, on the other hand, screened 685 individual prescription drugs and found that, among antihypertensive drugs, the use of amlodipine (calcium channel blocker), furosemide (loop diuretic), lisinopril (angiotensin-converting enzyme inhibitor/ACEI), or metoprolol (beta blocker) was associated with a lower risk of ALS [6]. The gene discussed is ACE; the disease is amyotrophic lateral sclerosis.