TGFB1 and neoplasm: Moreover, cancer-derived EVs can transport various cargoes for broad enhancement of immune suppression, such as heat shock protein 72 (HSP72) for promoting suppressive functions of myeloid-derived suppressor cells (MDSCs) [148], miRNAs and lncRNAs for boosting activation of M2-like pro-tumor macrophages [149], and TGF-β1 for augmenting differentiation of regulatory T cells (Treg) [150].