In addition to dedicated HF outcomes studies, a reduced risk of HHF in patients with T2D has also been demonstrated consistently in diabetes CVOTs and in renal outcomes studies across a range of SGLT2 inhibitors, including empagliflozin (EMPA-REG OUTCOME, RRR 35%) [27], canagliflozin (CANVAS/CANVAS-R, RRR 33%; CREDENCE, RRR 39%) [30, 36], dapagliflozin (DECLARE-TIMI 58, RRR 27%) [37] and ertugliflozin (VERTIS CV, RRR 30%) (Fig. 2A) [16]. The gene discussed is SLC5A2; the disease is hydrops fetalis.