Notably, sotagliflozin has both SGLT1 and SGLT2 inhibitory activity and is not a licensed treatment for T2D (but is licensed for type 1 diabetes in Europe), and SCORED was a cardiorenal study (patients had T2D and CKD) that used a different 3P-MACE outcome (CV death, HHF and urgent visits for HF) than the other studies (CV death, nonfatal MI and nonfatal stroke). The gene discussed is SLC5A2; the disease is type 2 diabetes mellitus.