Cardioprotective benefits of GLDs were first observed in the EMPA-REG OUTCOME trial, in which the SGLT2 inhibitor empagliflozin showed a 14% reduction in the risk of 3P-MACE compared with placebo (HR [95% CI] 0.86 [0.74–0.99], p = 0.04) in patients with T2D and established CVD [27]. This evidence concerns the gene SLC5A2 and type 2 diabetes mellitus.