Subsequently published CVOTs, as well as a small number of HF and renal outcomes studies, have added further paradigm-shifting evidence for improvements in CV, HHF and renal outcomes during treatment with other GLDs, such as the SGLT2 inhibitor canagliflozin, in patients with T2D (Table 1; Additional file 1: Table S1) [15, 16, 27, 30–37]. This evidence concerns the gene SLC5A2 and hydrops fetalis.