This is demonstrated by two clinical trials treating patients with unresectable stage IIIB-IV melanoma with T-VEC in combination with either ipilimumab, an anti-CTLA-4 antibody, or pembrolizumab, an anti-PD-1 antibody, reaching objective response rates of 39% [13] and 62% [14] respectively. This evidence concerns the gene PDCD1 and melanoma.