In patients who showed persistent CE, cytokines associated with eosinophilic activity including Eotaxin and inflammatory cytokine including IL-6 were persistently elevated from hyperacute to subacute stage of SAH, and regulatory cytokine such as sCD40L and inflammatory cytokine including TNF-α was transiently higher, especially at 6–8 days after stroke. The gene discussed is CD40LG; the disease is Stroke.