Herein, CAAT of tumor margins of obese IBC patients is characterized by the secretion of inflammatory mediator IL-6, IL-8, and MCP-1 that plays a significant role in proliferation, motility, invasion, induction of proteolytic activity, and drug resistance in the tumor microenvironment as described before by the authors (Mohamed et al., 2014 and 2021). This evidence concerns the gene CXCL8 and inflammatory breast carcinoma.