CXCL8 and neoplasm: Herein, CAAT of tumor margins of obese IBC patients is characterized by the secretion of inflammatory mediator IL-6, IL-8, and MCP-1 that plays a significant role in proliferation, motility, invasion, induction of proteolytic activity, and drug resistance in the tumor microenvironment as described before by the authors (Mohamed et al., 2014 and 2021).