CXCL8 and obesity due to melanocortin 4 receptor deficiency: However, this study also had several limitations: (1) this intriguing observation requires further study to determine whether the prominent IL-6, IL-8, and MCP-1 adipokines affect CSCs by knockdown them, and future studies using larger patient cohorts will help define their total prognostic and predictive value in IBC, and (2) the interpretation of the results obtained for the IL-6, IL-8, and MCP-1 cytokines in correlation with BMI was limited because the patients were nearly obese due to the increased obesity rate in Egypt [68], which may contribute to BC.