Moreover, significant upregulation of the in IL-6 mRNA was detected (P = 0.006) in IBC patients with obesity who had lymph node (LN) metastasis (n = 10; Fig. 3D, the left panel) when compared with the non-IBC group (n = 17) for which its expression was not changed (P = 0.324; Fig. 3D, right panel). This evidence concerns the gene IL6 and obesity due to melanocortin 4 receptor deficiency.