IL6 and breast cancer: In BC, the alteration of the adipokine profile, including molecules such as IL-6, IL-8, and MCP-1, has a significant impact on cancer progression [2] as it promotes cancer proliferation and invasion, controls epithelial derived-proteins and the production of growth factors, and induces other cells of the tumor microenvironment (TME), to trigger invasion [35] via different mechanisms such as the induction of cancer stem cell-like traits and the modulation of the influencing epithelial–mesenchymal transition (EMT) [39].