However, other non-CAH genetic etiologies have been gradually established, such as NR5A1/SF-1, NROB1/DAX-1, ABCD1 and PEX1. The GNAS gene encodes the alpha-subunit of the G protein (Gsα) which mediates the signalling of numerous peptide hormones such as parathyroid hormone (PTH), thyroid stimulating hormone (TSH), growth hormone–releasing hormone (GHRH), adrenocorticotropic hormone (ACTH), and gonadotrophins. Here, NR0B1 is linked to congenital adrenal hyperplasia.