On multivariate logistic regression analysis, apoA-I (OR 0.037, 95% CI 0.002–0.695), stenting time (OR 1.017, 95% CI 1.003–1.031), and diabetes (OR 2.853, 95% CI 1.027–7.930) were independent risk factors for late ISR after adjusting for sex, age, hypertension, smoking status, TG, LDL-C, hs-CRP, eGFR, LVEF, and other confounding factors. The gene discussed is APOA1; the disease is Hypertension.