CD3D and adult T-cell leukemia/lymphoma: This was the most notable gene cluster which included the genes CD3D, CD3E, and CD3G which are part of the KEGG pathway for Human T-cell Leukemia Virus type 1 (HTLV-I) infection (KEGG pathway hsa05166), and HTLV-I infections are a known risk factor for developing adult T-cell leukemia/lymphoma [13].