SIRT1 and breast cancer: With regard to the molecular subtype of BC, the meta-analysis of multivariate estimates provided evidence that high SIRT1 expression was significantly related to poor DFS in TNBC (HR = 1.82, 95% CI 1.28–2.59) rather than in HRBC (HR = 0.54, 95% CI 0.12–2.41, p = 0.423; Table 3).