TP53 and breast cancer: Moreover, Zhang et al. discovered a small-molecule activator of SIRT3 can inhibit the proliferation and migration of BC cells through SIRT3-driven autophagy/mitophagy signaling pathways [58]. In addition, SIRT3 could inhibit the oncogenic capacity of BC cells via increasing p53 expression and could suppress BC metastasis by repressing Src oxidation [59].