Nevertheless, whether existing antidepressants like bupropion have benefit as monotherapy in MDD with higher levels of CRP warrants investigation, as per our ongoing study collecting preliminary evidence of the efficacy of bupropion versus escitalopram to increase VS-vmPFC rs and/or tbFC in association with reduced anhedonia in MDD patients with CRP > 2 mg/L (NCT04352101). Here, CRP is linked to major depressive disorder.