CRP and major depressive disorder: We previously reported that increased plasma C-reactive protein (CRP) concentrations, as well as inflammatory cytokines and their soluble receptors, were associated with low resting-state (rs)FC between the left ventral striatum (VS) and ventromedial prefrontal cortex (vmPFC), key structures of classic reward circuitry that receive mesolimbic and mesocortical dopamine input [26], that correlated with anhedonia in medically stable and unmedicated MDD patients [19].