In the fully adjusted model (adjusted for age, BMI, gender, smoking status, ethanol consumption, regular exerciser, SBP, DBP, ALT, AST, GGT, HbA1c, FPG, TC, TG, HDL-C), the association between central obesity and incident diabetes was still detected (HR = 1.72, 95% CI 1.16–2.56, P = 0.0074). The gene discussed is GPT; the disease is diabetes mellitus.