IGHG3 and infection: Follow-up analyses on the HVTN 505 trial revealed correlates of risk of infection – on one hand, elevated HIV-specific antibody binding to FcγRIIa, ADCP, and anti-Env IgG3 breadth correlated with reduced acquisition risk, while on the other hand, HIV-specific IgA modulated the association of Fc function with HIV-1 risk41.