When Qiao et al. experienced a case of colon adenocarcinoma associated with diffuse ganglioneuromatosis, they suggested that glial cell line-derived neurotrophic factor (GDNF) and neurturin (NTN) expression in adenocarcinoma cells may play an important role in the pathogenesis of IGNM [13]. This evidence concerns the gene NRTN and adenocarcinoma.