Interestingly, second-order statistical textural features, such as the gray-level size zone matrix (GLSZM) and gray-level run length matrix (GLRLM), appeared to be more frequently selected by the GA-RF classifiers and F-score, suggesting that these feature types are capable of better capturing the heterogeneous characteristics of the MGMT methylation status of GBM tumors. Here, MGMT is linked to glioblastoma.