IFNG and infection: The bone marrow derived macrophages (BMDMs) isolated from the wild type (Fig. 7a, b) and the Gbpchr3−/−,chr5−/− mice (Fig. 7d, e) were left untreated or were primed with IFN-γ, followed by infection with the Y. pestis 201 or ΔyspE2, and bacterial survival percentage was analyzed by plating and counting of living bacteria released from BMDMs.