Studies have shown that blockade of sEH reduces neuropathology-associated inflammation29,30, resulting in cognitive improvement in the bilateral carotid artery stenosis (BCAS) model of VCI31, however these studies do not inform as to whether sEH is sufficient to induce VCI, or whether it is upregulated as a consequence of VCI, nor do they inform us of the cell type responsible for the observed improvement in outcome. This evidence concerns the gene EPHX2 and coronary atherosclerosis measurement.