AKT1 and cancer: The KEGG analysis showed that the downregulated genes were associated with metabolic pathways, glycolysis/gluconeogenesis, and PPAR signaling pathway (Supplementary Fig. 15), whereas the upregulated genes were associated with cytokine-cytokine receptor interaction, ECM-receptor interaction, pathways in cancer, regulation of actin cytoskeleton, phagosome, and PI3K-Akt signaling pathways (Supplementary Fig. 16).