It has been shown that overexpression of Fra-1 and Fra-2 blocks the progression of NAFL and NASH induced by a high fat diet (HFD) by suppressing transcription of Pparg through the action of inhibitory c-Jun/Fra-1 or c-Jun/Fra-2 heterodimers49, whereas elevated c-Jun promotes progression of NASH50,51. This evidence concerns the gene PPARG and metabolic dysfunction-associated steatohepatitis.