IGFBP1 and metabolic dysfunction-associated steatohepatitis: In the present study, we show that nuclear WTAP is downregulated in NASH, and hepatic deletion of Wtap leads to NASH-like phenotypes due to increased lipolysis in eWAT, increased hepatic FFAs uptake and inflammation, which are strongly associated with increased expression of Igfbp1, Cd36 and cytochemokines such as Ccl2, respectively.