In other mouse model such as liver-specific carnitinbe palmitoyltransferase 2 (Cpt2) knockout mice, Igfbp1, Fgf21 and Gdf15 are induced under a ketogenic diet feeding condition, which likely leads to enhanced lipolysis in WAT, finally resulting in severe NASH with a complete absence of adipose triglyceride stores43. Here, CPT2 is linked to metabolic dysfunction-associated steatohepatitis.