It should be noted that other upregulated cytochemokines such as Tnfa, Il1β, Csf1, Ccl3, Ccl5, Ccl22, Cxcl2, Cxcl5 and Cxcl10 may also contribute to NASH progression in Wtap-HKO mice. The gene discussed is CXCL10; the disease is metabolic dysfunction-associated steatohepatitis.