However, Wtap-HKO mice displayed severe NASH phenotypes, as revealed by higher liver weight (Supplementary Fig. 2a, b), higher liver TAG levels (Supplementary Fig. 2c), more hepatic lipid droplets (Supplementary Fig. 2d), and higher serum ALT activities (Supplementary Fig. 2e) compared with Wtapflox/flox mice. This evidence concerns the gene WTAP and metabolic dysfunction-associated steatohepatitis.