BCR and infection: A recent study found no skewing in germline BCR pairings targeting the SARS-CoV-2 receptor binding motif (RBM) in unexposed individuals, consistent with observations that BCRs using IGHV1-69/IGKV3-11 pairing target (an) epitope(s) outside of the RBD51.This enriched genotype was observed after vaccination and after infection, where it increased in frequency over time19,20 as well as in a database attempting to collect all available anti-S MAb sequences (CoVAbDab), suggesting that the vast majority of patients developed this memory B cell subset52.