Functional OGG1 prevents obesity and metabolic dysfunction24,25 through altered PGC-1α expression and fatty acid oxidation25; reduced levels of PGC-1α has been reproducibly observed in T2D patients2,27,28 and have been related to increased levels of ROS and decreased levels of β-oxidation enzymes29. Here, PPARGC1A is linked to obesity due to melanocortin 4 receptor deficiency.