Together with EZR (Ezrin) and RDX (Radixin), MSN comprises the ERM family, which members are reported to function as cross-linkers between transmembrane proteins, i.e., CD44, EGFR or other receptor tyrosine kinases, and the actin cytoskeleton, thereby regulating processes such as adhesion and cell migration, and all members have been implicated in cancer progression37–42. This evidence concerns the gene CD44 and cancer.