Targeting Stat6 inhibitor AS1517499 to inhibit M2 activation: Previously, we have studied the role of STAT6 pathway, the IL-4/IL-13 mediated downstream pathway, in inhibition of M2 differentiation and M2-driven tumor cell migration in breast tumor model using the STAT6 inhibitor AS1517499 (AS)22. The gene discussed is STAT6; the disease is neoplasm.