For example, miR-26a, an inflammatory suppressor that targets Toll-like receptor-3 (TLR3) to ameliorate arthritis severity,153 can be induced by estrogen in FLSs, while its downregulation is observed in exosomes from female OA patients, which possibly provides hints to explain the increased prevalence and severity of OA in females than in males. The gene discussed is TLR3; the disease is arthritic joint disease.