RNF6 and chronic myelogenous leukemia, BCR-ABL1 positive: The subsequent analysis revealed that P5091 downregulated RNF6 at its protein level, along with the cleavage of PARP and Caspase-3, hallmarks of cell apoptosis (Fig. 5A), indicating P5091 induces MM and CML cell apoptosis that might be at least partly contributed by RNF6 degradation.