Several signaling pathways contributing to the oncogenesis of TRE17 have also been identified: TRE17 increases the production of MMPs and promotes tumorigenesis of osteosarcoma cells through the activation of NF-κB and Jack1-STAT3 pathways, respectively (15, 16, 17, 18). The gene discussed is NFKB1; the disease is osteosarcoma.