Chromosomal translocation of the TRE17 locus leading to overexpression of its wildtype protein is associated with various bone and soft tissue neoplastic lesions, especially in aneurysmal bone cyst (ABC) and nodular fasciitis (NF), in which TRE17 is translocated nearly 70% and more than 90% of cases, respectively (5, 8, 9, 10). The gene discussed is USP6; the disease is nodular fasciitis.