Certain frequent clinicopathological features and copy-number changes (e.g., metastatic disease, MYC amplification, LCA histology, i17q, loss of chromosome 8, gain of chromosome 5) are significantly non-randomly distributed with respect to G3/G4 continuum, even within individual subtypes (Figures S4B and S4C). The gene discussed is MYC; the disease is Leber congenital amaurosis.