AZIN1 and hepatocellular carcinoma: One such RNA editing site is AZIN1 chr8:103841636T>C, known to result in a S367G substitution that causes conformational changes, cytoplasmic-to-nuclear translocation, and gain of function, increasing tumor potential in hepatocellular carcinoma (Chen et al., 2013), non-small cell lung cancer (Hu et al., 2017), colorectal cancer (Shigeyasu et al., 2018), and gastric cancer (Okugawa et al., 2018) (Figure 4D).