Following a similar theme, monoubiquitylation of UBE2T at K86 (5 amino acids from the catalytic cysteine K91) is suggested to reduce E2 activity linked to the Fanconi anemia DNA repair pathway mediated by the E3 ubiquitin ligase FANCL (Machida et al., 2006). The gene discussed is UBE2T; the disease is Fanconi anemia.